Omega-3 (EPA/DHA)

The most evidence-backed supplement for systemic inflammation.

What it is

Omega-3 fatty acids — primarily EPA and DHA — are long-chain polyunsaturated fats found in oily fish and algae. Most people eating a Western diet are significantly deficient.

Why it matters

EPA and DHA reduce the production of pro-inflammatory eicosanoids and cytokines. High-dose omega-3 supplementation has been shown to lower CRP, reduce triglycerides, and support immune modulation. In oncology contexts, omega-3s are studied for their potential to preserve lean muscle mass and reduce cachexia.

The evidence

Multiple meta-analyses support high-dose omega-3 for inflammation reduction. The REDUCE-IT trial (2018) showed significant cardiovascular benefit at 4g/day EPA. Dosing in serious illness typically ranges from 2–4g/day of combined EPA+DHA.

This information is for educational purposes and does not constitute medical advice. Always discuss supplement use with your care team, particularly if you are undergoing active cancer treatment.

Dosing

2–4g EPA+DHA daily. Take with food containing fat for best absorption.

Cautions

Can thin blood at high doses — relevant if you are on anticoagulants. Check with your oncologist if undergoing chemotherapy, as some protocols have interactions.