Total Bilirubin

A liver and haemolysis marker — elevated levels appear as jaundice.

What it is

Bilirubin is produced by the breakdown of haemoglobin. Total bilirubin is the sum of direct (conjugated) and indirect (unconjugated) forms. It is processed by the liver and excreted in bile.

Why it matters

Elevated total bilirubin can signal liver impairment (from treatment toxicity or disease), bile duct obstruction, or increased red blood cell destruction (haemolysis). Monitoring it ensures the liver is tolerating treatment.

How to test

Standard liver panel blood test.

This information is for educational purposes only. Always discuss testing and interpretation of results with your care team.

Optimal range

Below 17 µmol/L

normal

Above 34 µmol/L

investigate liver function or haemolysis

How often

Every 6–12 weeks alongside liver enzymes during treatment.