Melatonin

Not just a sleep hormone. One of the more interesting molecules in oncology research.

What it is

Melatonin is a pineal hormone that regulates circadian rhythm. At pharmacological doses (well above what the brain produces), it also acts as a direct antioxidant and has immunomodulatory effects.

Why it matters

Sleep quality is foundational for recovery, immune function, and emotional resilience. Melatonin at higher doses is being studied specifically in oncology for its potential to improve treatment tolerance and quality of life. Some trials have used doses of 10–40mg nightly.

The evidence

A 2017 meta-analysis in Cancer Epidemiology found high melatonin use associated with reduced cancer risk. Smaller trials in active disease contexts have shown improvements in treatment tolerance and sleep. The science is still developing but the side effect profile at moderate doses is very low.

This information is for educational purposes and does not constitute medical advice. Always discuss supplement use with your care team, particularly if you are undergoing active cancer treatment.

Dosing

3–20mg taken 30–60 minutes before sleep. Start at 3mg and titrate. Use with a consistent sleep schedule for best results.

Cautions

High doses can cause vivid dreams, morning grogginess, or hormonal interactions. Not recommended during pregnancy. Discuss with your oncologist if on immunotherapy (theoretical concerns about immune modulation).